Prospective Surveillance for IFI in HSCT Recipients
نویسندگان
چکیده
Dimitrios P. Kontoyiannis, Kieren A. Marr, Benjamin J. Park, Barbara D. Alexander, Elias J. Anaissie, Thomas J. Walsh, James Ito, David R. Andes, John W. Baddley, Janice M. Brown, Lisa M. Brumble, Alison G. Freifeld, Susan Hadley, Loreen A. Herwaldt, Carol A. Kauffman, Katherine Knapp, G. Marshall Lyon, Vicki A. Morrison, Genovefa Papanicolaou, Thomas F. Patterson, Trish M. Perl, Mindy G. Schuster, Randall Walker, Kathleen A. Wannemuehler, John R. Wingard, Tom M. Chiller, and Peter G. Pappas
منابع مشابه
Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne.
BACKGROUND The purpose of our study was to evaluate the incidence and outcome of invasive fungal infection (IFI) among patients who underwent autologous or allogeneic hematopoietic stem cell transplantation (HSCT) at 11 Italian transplantation centers. METHODS This cohort-retrospective study, conducted during 1999-2003, involved HSCT patients admitted to 11 tertiary care centers or university...
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Patients who receive a hematopoietic stem cell transplantation (HSCT) exhibit an immune defect after recovering from neutropenia. The current guidelines do not recommend fungal prophylaxis in these patients, except for grades III to IV GVHD in HSCT. Thus, the timing for the initiation and cessation of IFI prophylaxis in immune-compromised patients remains a challenging endeavor. We retrospectiv...
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To the Editor—Using the Prospective Antifungal Therapy (PATH) Alliance registry, Neofytos et al. [1] investigated the epidemiology and outcome of invasive fungal infections (IFIs) in hematopoietic stem cell transplant (HSCT) recipients. Because use of Web-based registries is pivotal for progress in understanding IFIs, the Italian Hema e-Chart Group is also engaged in a prospective, multicenter,...
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Acute graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT). It has been proposed that tumor necrosis factor alpha (TNF-alpha) blockade with infliximab may be an effective treatment for severe (grades III-IV) GVHD. We determined if infliximab use in this high-risk population was associated with an additional increased risk of non-...
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Invasive fungal infections (IFI) represent a major hindrance to the success of hematopoietic stem cell transplantation (HSCT), contributing substantially to morbidity and infection-related mortality. During the most recent years several reports indicate an overall increase of IFI among hematologic patients, in particular, invasive aspergillosis, that may be explained, at least partially, by the...
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